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10.1007/s10876-015-0917-3 [DOI] [Google Scholar] Wahab A., Muhammad M., Ullah S., Abdi G., Shah G

Hypoxia increases anaerobic glycolysis by activating HIF (130) and hypoxia-induced LDHA and HKII promote PI-resistance in MM cells (45)

Creatine does this by increasing the bodys ability to produce adenosine triphosphate (ATP), which provides energy to cells

Future studies ought to employ multi-omics methodologies, including metabolomics, proteomics, transcriptomics, and microbiome analysis, to elucidate the intricate molecular networks that govern the interactions between muscle and vascular systems

Gomez-Ferrer, M

Therefore, localized administration methods, such as intra-articular injection or combination with sustained-release carriers, are considered more feasible and safer clinical translation pathways